Serum Arginase , a biomarker of treatment efficacy in human African
نویسندگان
چکیده
5 Romaric Nzoumbou-Boko, Mariette Dethoua, Fréderic Gabriel, Alain 6 Buguet, Raymond Cespuglio, Pierrette Courtois, Sylvie Daulouède, Bernard 7 Bouteille, Stéphane Ngampo, Ghislain Mpandzou, Silla Semballa, Philippe 8 Vincendeau 9 1 Laboratoire de Parasitologie, UMR 177 IRD CIRAD, BP 43, Université de Bordeaux, 33076 10 Bordeaux cedex, France 11 2 Laboratoire de Parasitologie, University Hospital of Bordeaux, 33076 Bordeaux cedex, France 12 3 Polyclinique Marie-Louise Poto-Djembo, B.P. 49, Pointe-Noire, Republic of Congo (Brazzaville) 13 4 Centre de recherche en neurosciences de Lyon, Inserm U-1028, CNRS UMR-5292, Claude14 Bernard Lyon 1 University, 69373 Lyon cedex, France 15 5 Parasitology Department, University Hospital of Limoges, 87042 Limoges cedex, France 16 6 National Control Programme for Human African Trypanosomiasis, Brazzaville, Republic of 17 Congo 18 7Neurology Ward, University Hospital of Brazzaville, Republic of Congo 19 20 Corresponding author. Mailing address: Laboratoire de Parasitologie, BP 43, UMR 177 21 IRD CIRAD Université de Bordeaux, 33076 Bordeaux cedex, France 22 E-mail: [email protected] 23 24 *RNB and MD contributed equally to this article 25 Copyright © 2013, American Society for Microbiology. All Rights Reserved. J. Clin. Microbiol. doi:10.1128/JCM.03371-12 JCM Accepts, published online ahead of print on 3 April 2013
منابع مشابه
Serum arginase, a biomarker of treatment efficacy in human African trypanosomiasis.
Arginase serum levels were increased in human African trypanosomiasis patients and returned to control values after treatment. Arginase hydrolyzes l-arginine to l-ornithine, which is essential for parasite growth. Moreover, l-arginine depletion impairs immune functions. Arginase may be considered as a biomarker for treatment efficacy.
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